In conclusion, the results of this study confirm a wide overexpression of TLR3, TLR7, and TLR9 in kidney sections of LN patients and demonstrate a correlation with clinical and histological indices, further supporting a putative role for these mediators of innate immune response in the pathogenesis of lupus nephritis and suggesting them as potential therapeutic target. This evidence concerns the gene TLR7 and lobular neoplasia.