In addition, there is also growing evidence on the functional role of the ED-A domain of fibronectin in the process of myocardial remodeling by mediating the transdifferentiation of fibroblast to MyoFb as well as by activating vascular smooth muscle cells in the tunica media of vessel structures contributing to vascular remodeling, for example, in allograft vasculopathy or classic atherosclerosis [14, 54, 55]. The gene discussed is FN1; the disease is atherosclerosis.