Of note, we observed some cells stained with E-cadherin in the edges of the tumor specimens and these staining showed no expression difference between H460 H-INV and H460 L-INV, and lower expression in H1299 H-INV-derived xenograft tumors when compared to that of H1299 L-INV (Figure 1F and 1G). The gene discussed is CDH1; the disease is neoplasm.