In the KIRC relevant modulatory network, the modulatory relationship HCG18- EGFR appeared up to 10 pathways, of which 7 pathways were cancer-related such as focal adhesion, such as MAPK signaling pathway and etc. TCGA data set include miRNA expression data, we further analyzed the expression relationship between lncRNA, miRNA and mRNA. This evidence concerns the gene HCG18 and cancer.