Though functions of FDG5-AS1, WDFY3-AS2 and CTD -2302E22.2.1 were unclear, Subpathway-LNCE reveals that they may play important role in prostate cancer by competing cancer related miRNAs with PTEN to disturb the phosphatidylinositol signaling system. The gene discussed is PTEN; the disease is Familial prostate cancer.