HIF1A and metastatic malignant neoplasm in the lymph nodes: Importantly, high stromal HIF-1α expression remained an independent unfavorable prognostic factor (hazard ratio (HR) of 1.7, p = 0.04) in a Cox proportional hazards model, when adjusted for epithelial HIF-1α expression, patient age, histological type and grade, myometrial invasion and lymph node metastasis (Table 3), epithelial HIF-1α expression failed to reach statistical in the same multivariate analysis (p = 0.97).