The authors would like to thank Drs. Steven Ades and Scott Perrapato for their insight and guidance on prostate cancer diagnosis, treatment, and needs in the clinic, Kristiaan Finstad for all mouse husbandry and aid in prostate dissections, Dr. Jon Ramsey in the Clinical Translational Research Laboratory at the University of Vermont Cancer Center for providing siRNA against Runx2, and all members of our laboratory for their helpful comments and suggestions in preparing this manuscript. The gene discussed is RUNX2; the disease is prostate carcinoma.