The latter is consistent with the observed upregulation of Runx1 and Runx2 when PTEN is downregulated by 21 weeks in the diseased TRAMP prostate (Figure 1A, 1B, 1G), while the former supports the proposed idea that mutual activation of Runx and PI3K/AKT signaling promotes tumor progression [2]. The gene discussed is RUNX2; the disease is neoplasm.