MCM4 and acute promyelocytic leukemia: For example, regarding the cellular proliferation in model 1 (Figure 3A), the up-regulation of E2F1 and MYC mRNAs and the down-regulation of PKMYT1 mRNA seemed to indicate an enhanced proliferation of peripheral blood APL cells, whereas the concurrent down-regulation of MCM4 mRNA seemed to predict suppression of cellular proliferation.