Piperlongumine exerts anti-tumor effects through a variety of pathways, including the induction of reactive oxygen species (ROS) accumulation, activation of C/EBP homologous protein (CHOP), suppression of LMP-1 (EBV-encoded oncogene) expression, activation of AMPK phosphorylation, inhibition of NF-κB, and promotion of autophagy [10–17]. This evidence concerns the gene DDIT3 and neoplasm.