While Fiorucci et al.12 and Úbeda et al.36 reported decreased hepatic fibrosis upon preventive OCA-treatment in porcine serum-induced and CCl4–induced liver fibrosis respectively, their findings were contrasted by the data of Fickert et al.15, finding unaltered effect on fibrosis upon CCl4- or S. mansoni-mediated liver injury in animals with genetic FXR-loss. Here, NR1H4 is linked to Hepatic fibrosis.