Furthermore, the activation of FXR by means of highly potent and selective FXR agonists such as obeticholic acid (OCA) has been suggested to reduce fibrosis in two experimental models of early-stage liver fibrosis either by 2 weeks bile-duct ligation or after 12 weeks of treatment with porcine serum12. This evidence concerns the gene NR1H4 and Hepatic fibrosis.