NR1H4 and Cirrhosis: Given this background and controversies, we aimed to explore, both prophylactically as therapeutically, the effects of FXR-agonism by means of OCA, an oral first-in-class FXR agonist, on hepatic inflammation and fibrosis in a model of toxic non-cholestatic cirrhosis by means of thioacetamide ingestion in rats and to correlate these findings to different cytokines and parenchymal and non-parenchymal cell types exposed to FXR-agonism in vitro.