These findings suggest that the documented resolution of fibrosis observed in cirrhotic rats not only relates to the inhibition of pro-fibrotic signals on HSC as such, but is also critically influencing other determinants of hepatic fibrosis such as ECM degradation, inflammation, proliferation and apoptosis and adds up to the pleiotropic effects of FXR-agonism. Here, NR1H4 is linked to Hepatic fibrosis.