USP16 and neoplasm: We further corroborated the suppressive effects of USP16 on the oncogenic activities of Ct-HBx in vivo by injecting HBxΔ35-transduced Huh7 cells and HBxΔ35, USP16-cotranduced Huh7 cells into nude mice and measuring the sizes and weights of the xenograft tumours after 3 weeks.