PTGS1 and Cognitive impairment: Similarly, although the neuroanatomy and molecular mechanisms of sickness-induced hypoactivity remain poorly understood both indomethacin (Teeling et al., 2007) and the COX-1 inhibitor sc-560 (Griffin et al., 2013) reduced measures of LPS-induced sickness behavior and cognitive deficits without effect on systemic or central TNF-α.