TNF and Sepsis: Moreover, plasmacytoid dendritic cells promote the function of regulatory T Cells, which increase the production of anti-inflammatory factors, such as IL-10 and TGF-β, and reduce the pro-inflammatory cytokines, such as IL-2, IL-6 and TNF-α, so that to combat against the pro-inflammatory cytokines storm in early period of sepsis and then modulate the over-stimulating of nonspecific immunity in the deferment period later on [49].