Members of other HDACs, such as SIRT1, HDAC2 and HDAC4, are found to be involved in diabetic kidney disease (DKD), including DN12, 13, 14, through regulating podocytes apoptosis, excessive accumulation of ECM, epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells and inflammation. This evidence concerns the gene SIRT1 and diabetic kidney disease.