MAPK8 and neoplasm: The results demonstrated that compound 3k not only suppressed tumor growth and angiogenesis but also blocked tumor cell migration, and subsequent mechanism exploration suggested that this series of compounds took effect mainly through angiogenesis signaling pathways, such as FAK-Src-Paxillin, JNK-c-Jun and ERK1/2-c-Jun, etc. All of the results indicate that these compounds are attractive as potential candidates for the treatment of tumor growth and metastasis in future.