Furthermore, the in vivo tumorigenicity experiment results showed that 1 × 103 CD133+ SFCs cells could initiated tumor formation 18 days after inoculated Balb/c-nu mice, as compared to 31 days of tumorigenic latent period for 1 × 105 parental cells (Table 1, Fig. 3a). Here, PROM1 is linked to neoplasm.