In recent, an imputation-based genome wide association study had identified two rare variants rs11571833 (c.9976A > T) in BRCA2 (OR = 2.47, P = 4.74 × 10−20) and rs17879961 (c.470T > C) in CHEK2 (OR = 0.38, P = 1.27 × 10−13), which have large effect on lung cancer in populations of European ancestry17. The gene discussed is BRCA2; the disease is lung cancer.