A2ML1 and ocular melanoma: The first large-scale sequencing study on OM was performed by Santos-Cortez et al. By exome-sequencing two second cousins in a Filipino isolate where the prevalence of OM is almost 50%, a variant in A2ML1 (α-macroblobulin-like 1) was identified as a novel rare, but high risk, candidate variant for OM19.