Our OM susceptibility candidate region contains the genes PLD3 (Phospholipase d family, member 3), HIPK4 (Homeodomain-interacting protein kinase 4), PRX (Periaxin), SERTAD1 (Serta domain-containing 1), SERTAD3 (Serta domain-containing 3), and BLVRB (Biliverdin reductase b). The gene discussed is HIPK4; the disease is ocular melanoma.