The relative abundance of Ter119+CD71+ reticulocytes and mature Ter119+CD71- RBCs (identified as described in S6A Fig) was quantified in the blood of WT and Mif-/- mice at 3 months p.i., which corresponds with a time point when maximal cell numbers, level of hepato-splenomegaly and tissue pathogenicity were reached in both groups of mice (Figs 1C–1F and S3). Here, TFRC is linked to Splenomegaly.