The proteins encoded by several cancer-related genes (CTCF, RHOA, CDKN1B, and CUX1) were also implicated in viral replication identified by gene-trap, consistent with a previous report that host interactome and transcriptome network perturbations caused by DNA tumor virus proteins impair Notch signaling and apoptosis pathways, a conserved process in cancer [45]. The gene discussed is CTCF; the disease is cancer.