CD8A and infection: Others have shown that humoral responses against HEV can be detected more than 12 years after primary infection and that these contract over time (negative seroconversion rates 1.4%/year).58, 59 The capacity for secondary reinfection with HEV in some individuals27 may simply be a result of waning adaptive immune responses in the absence of HEV infection with a decline in CD8+ T‐cell polyfunctionality.