Although, we observed both damaging and benign mutations in putative HCC driver genes repeated in HCC tissue, mutations in the majority of these genes (except for CTNNB1 in dataset WES 2 and TP53 in datasets WES 2, 3 and 4) were also observed at similar frequencies in the surrounding non-tumour tissue (S3 Table). This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.