IGFBP3 and breast cancer: These results are biologically plausible since the IGFBP-3 rs2854744 AA genotype, DISI<9.85 mg/day, and BMI ≥24 kg/m2 may work together to increase circulating IGFBP-3 levels, which has been observed to be positively associated with the risk of BC among Chinese women [10].