IGF1 and breast cancer: Although we did not observe effects of IGF-1 rs1520220 and IGFBP-3 rs2854744 alone on BC, we did find joint effects of IGF-1 rs1520220 and BMI, IGFBP-3 rs2854744 and BMI, and IGFBP-3 rs2854744 and DISI using multivariable ULR.