Compared with the reference subgroup, BC risk was significantly higher for those with the IGFBP-3 rs2854744 AA genotype, BMI<24 kg/m2, and DISI<9.85 mg/day (OR = 1.95, 95%CI: 1.03–3.69), and for those with BMI≥24 kg/m2, DISI<9.85 mg/day and either IGFBP-3 rs2854744 genotype (OR = 2.13, 95%CI: 1.00–4.51). The gene discussed is IGFBP3; the disease is breast cancer.