Compared with the reference, the BC risk for those with BMI≥24kg/m2 was higher (OR = 2.69, 95%CI: 0.996–7.26), and the risk was still higher in the subgroups with both BMI≥24 kg/m2 and DISI<9.85 mg/day (OR = 4.95, 95%CI: 1.53–16.03), and both DISI<9.85 mg/day and the IGFBP-3 rs2854744 AA genotype (OR = 4.47, 95%CI: 1.69–11.85). This evidence concerns the gene IGFBP3 and breast cancer.