Compared with women with the IGFBP-3 CC+CA genotype and BMI<24 kg/m2, other groups (IGFBP-3 AA& BMI<24 kg/m2; IGFBP-3 CC+CA& BMI ≥24 kg/m2; IGFBP-3 AA& BMI≥24 kg/m2) had a significantly higher risk for BC. The gene discussed is IGFBP3; the disease is breast cancer.