Deal et al. demonstrated a synergetic effect of BMI>27 kg/m2 and carrying the IGFBP-3 rs2854744-A allele on increasing IGFBP-3 levels [33].The protective effect of dietary soy intake against breast cancer has been demonstrated by a number of studies in Asia (reviewed in [40]). Here, IGFBP3 is linked to breast carcinoma.