Moreover, the number of RANKL positive cells was significantly higher in subjects with PBC (7.36±0.92/HPF), compared with unaffected controls (2.21±0.28/HPF) (p<0.01) (Fig 1A), as well as in AIH (3.38±0.58/HPF, p<0.01), CHB (4.67±0.51/HPF, p<0.05) and PSC (3.00±0.33/HPF, p<0.01) subjects (Fig 1B). This evidence concerns the gene TNFSF11 and autoimmune hepatitis.