OPG expressing cells were significantly higher in PBC (5.45±0.47/HPF), compared with other chronic liver diseases, i.e. AIH (3.89±0.38/HPF, p<0.01), CHB (2.12±0.22/HPF, p<0.001) and PSC (2.81±0.72/HPF, p<0.001) (Fig 3B). Here, TNFRSF11B is linked to primary biliary cholangitis.