Importantly, RANK expression was found significantly higher in PBC (2.41±0.14) than AIH (1.74±0.13, p<0.01), CHB (0.97±0.12, p<0.001), and PSC (1.05±0.13, p<0.001) (Fig 2B). This evidence concerns the gene TNFRSF11A and primary biliary cholangitis.