Distinguishing a leiomyosarcoma from the most commonly encountered mesenchymal gastrointestinal tumor (i.e., the gastrointestinal stromal tumor, GIST [29], characterized by the presence of activating mutations in KIT or PDGFRA, and expression of CD 117 and/or CD34) is highly important. This evidence concerns the gene CD34 and gastrointestinal stromal tumor.