HPGDS and cancer: The polymorphisms affect the enzyme activity, leading to increased genotoxic damage and affect the transportation of steroid hormones, causing the development of cancer eventually.[107,108] GSTs are essential for maintaining genomic integrity because electrophilic compounds could damage the DNA.[109] Therefore, GSTA1, GSTM1, GSTP1, and GSTT1 may play an important role in the development of BCa.