MMP-8 plays an important role in a wide range of inflammatory disorders.[27] MMP-8 initiates the first step of collagen degradation by disrupting triple helical fibrillar collagen.[28] Billinghurst et al[29] suggested that increased expression of MMP-8 would have an effect on the cleavage of type II collagen in human cartilage of osteoarthritis (OA). Here, MMP8 is linked to osteoarthritis.