MMP8 and atherosclerosis: It is possible that rs1940475 has an effect on proMMP-8 activation by a glutamate-to-lysine substitution at amino acid residue 87 located in the propeptide of MMP-8.[31] The rs11225395 polymorphism has been shown by functional analysis to have an effect on MMP-8 promoter activity.[31] The rs1940475 and rs11225395 polymorphisms have been reported to have an association with atherosclerosis.