MiR-218 is a vertebrate-specific miRNA that has been predicted and experimentally confirmed to play a crucial role in tumorigenesis and tumor progression by regulating the expression of potential targets.[37,38] MiR-218 have found to serve as a candidate tumor suppressor in targeting multiple cancer by regulation of relative gene expression.[39,40] Mathew et al[41] identified a miR-218-RTK-HIF2α signaling axis which promotes tumor angiogenesis and glioblastoma multiforme (GBM) cell survival, especially for necrotic mesenchymal tumors. Here, EPAS1 is linked to mesenchymal cell neoplasm.