CDK6 and cancer: Meanwhile, it was demonstrated that silencing of miRNA-21 promotes migration and invasion of breast cancer through Slit2-Robo1 pathway.[42] Importantly, these results suggested that miR-218 acts as a potential tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma, including RICTOR, CDK6, and cathepsin B (CTSB).[43,44] However, significance of miR-218 expression with clinicopathological factors and/or prognosis of cancers are unclear.