Atherosclerosis is an inflammatory disease involved in accumulating of lipid in the arterial wall. PPAR α and PPAR γ control almost all phases of atherosclerosis formation. PPAR α decreased the density of LDL in patients with dyslipidemia [35], and its activation repressed the accumulation of oxidized-LDL in atherosclerotic plaques of insulin-resistant mice [36]. Here, INS is linked to metabolic syndrome.