MINO precancer and the invasive carcinomas arising from MINO (MINO tumor) with CK8/18, a marker of luminal epithelial cells and SMA, a marker for basal myoepithelial cells showed organized multi-lineage differentiation in the MINO precancer whereas invasive carcinoma cells have uniform cellular immunoreactivity for CK8/18 with SMA only in the smooth muscle cells associated with blood vessels (Figure 1). The gene discussed is KRT8; the disease is invasive carcinoma.