Other proteins that have been identified in the NDC include death-associated protein kinase 1 (DAPK1), a death-signaling protein [127] that is recruited to the NDC via its interaction with GluN2B following stroke challenge [128], PTEN [129], a well-characterized cell death-promoting molecule that was recently identified as a crucial component of the NDC [91, 130], and finally calpains, a family of Ca2+-activated cysteine proteases that plays a major role in translating the Ca2+ influx of NMDARs into neuronal damage [120, 131, 132] (components shown in Figure 2). The gene discussed is DAPK1; the disease is Stroke.