BRCA2 and pancreatic neoplasm: BRCA2 germline mutations are the most frequent genetic alteration in familial pancreatic cancer and occur in 5–20% of the patients (Murphy et al., 2002; Hahn et al., 2003; Couch et al., 2007; Dagan, 2008; Ferrone et al., 2009; Ghiorzo et al., 2012; Luo et al., 2015; Zhen et al., 2015).