In addition, a subset of the cell lines has mutations in genes that were previously linked to a cancer phenotype, including KRAS (in MDA-MB-231, MIA PaCa-2, Capan-2, AsPC-1, and HCT 116) and CDKN2A (in MCF7, MDA-MB-231, and HCT 116). The gene discussed is CDKN2A; the disease is cancer.