BRCA1 and cancer: Over-expression of miR-19a/miR-19b often correlates with loss of BRCA1/BRCA2 protein expression in breast, ovarian cancer, pancreatic, and other cancers (King, 2004; Malone et al., 2009; Li et al., 2010), which raised the possibility that miR-19a/miR-19b could be involved in the regulation of BRCA2; however, we are not aware of any earlier reports that demonstrated direct targeting of BRCA2 mRNA by members of the miR-17/92 cluster and regulation of its mRNA and protein abundance.