CRP and Increased total leukocyte count: For example, lysates did not increase leukocytosis, sedimentation rate, and the concentration of C-reactive protein (CRP) in patients; furthermore, in individuals with the initial CRP concentration above 10 mg/l, a significant reduction in the concentration of this protein was shown between days 9 and 32 of treatment (Międzybrodzki et al., 2012).