LYN and chronic pancreatitis: Our findings with human primary stellate cells support targeting Lyn in chronic pancreatitis patients by showing that Lyn activity is differentially expressed in stellate cells of chronic pancreatitis compared to normal subjects, and inhibition of Lyn leads to the significant chemotaxis and proliferation decrease of primary chronic pancreatitis stellate cells in vitro, while leaving chemotaxis and proliferation of normal stellate cells only slightly affected (Figures 1, 2).