However, since Lyn is also directly associated with invasive cell phenotype, including aberrant cell movement, infiltration and prolonged viability (Ptasznik et al., 2002, 2004; Nakata et al., 2006; Malik et al., 2008), it is possible that the hyperactive Lyn (Figure 1A) is simply driving invasiveness of activated myofibroblasts in pancreatitis, leading ultimately to fibrosis. The gene discussed is LYN; the disease is pancreatitis.