CXCL12 and neoplasm: It has been reported that stromal cells produce cytokines IL-4 and IL-21, which bind to interleukin receptor on lymphoma cells (IL-4R/IL-21R) or chemokines CXCL12 and CXCL13, thus forming the complex which is also implicated in evolution of tumor microenvironment and moreover in acquirement of malignant properties by cells [127].