Consequently, as the Vert-X mice are transcriptional reporters (30), these data imply that uniform and stable transcription of IL-10 mRNA does not occur in malaria-specific activated CD4+YFP+GFP+ T cells during and/or after malaria infection, suggesting that the IL-10 gene is not epigenetically imprinted for poised production in these cells. The gene discussed is CD4; the disease is malaria.