Correspondingly, a significantly higher frequency of CD4+YFP+GFP− T cells exhibited an effector memory T cell signature (CD44+CD62Llow, IL-7R+, CD103−KLRG-1−) after clearance of infection compared with CD4+YFP+GFP+ T cells (Fig. 2B), and the proportion of CD4+YFP+GFP− T cells exhibiting an effector memory T cell phenotype increased with time during the memory maintenance phase postinfection (Fig. 2B). This evidence concerns the gene CD4 and infection.