TP53 and metastatic neoplasm: The cell lines used were derived from the primary colorectal carcinoma (CRC): HCT116 (WT TP53) and SW480 (mutant p53R273H), and from metastatic tumors: LoVo (WT TP53), SW620 (mutant p53R273H) and CoLo205 (mutant p53, Y103 del27bp).