TP53 and cancer: In addition, as missense mutations of TP53 do not totally abrogate its tumor suppressor activity and can confer additional biological activities to TP53 gene, it is very difficult to choose the most efficient cancer treatment based on TP53 mutation status (Kruiswijk et al., 2015; Lang et al., 2004; Li et al., 2012; Meek, 2015).