To confirm the role of Δ133p53 isoforms in cell invasion, we knocked-down these isoforms in mutant TP53 SW620, or WT TP53 LoVo CRC cells by using si133-1 and si133-2, which led to a significant decrease invasive capacity in both cell lines (Figure 4D and Figure 4—figures supplement 1A and B). The gene discussed is TP53; the disease is colorectal carcinoma.