Offering a neuropathological perspective, Tammaryn Lashley (University College London (UCL), UK) showed changes in the expression of multiple heterogeneous nuclear ribonucleoproteins (hnRNP) between FTD-TDP-43 and FTD-FUS subtypes, highlighting the different mechanisms that could underlie these diseases. Here, TARDBP is linked to frontotemporal dementia.