Rodríguez-Viales et al.32 published a study of two PAH families in which index patients showed one mutation in the 5′UTR region of BMPR2 gene described by Wang et al.33 in an IPAH patient, along with another mutation in the coding region of BMPR2 or in the ENG gene, respectively. Here, BMPR2 is linked to idiopathic pulmonary arterial hypertension.