THBD and Sepsis: As mentioned before, the efficacy of anticoagulants depends on the severity of the sepsis [4, 26, 27], and the efficacy of recombinant thrombomodulin was revealed in a population in which the post-treatment mortality was 20 % or more [4, 28], but it might not be efficient in a population with a mortality rate of less than 20 % [4, 26].