They are also in accord with our demonstration that TGF-β1 induction in IL-13 Tg mice is mediated by the canonical IL-13 receptor (IL-13Rα1-IL-4 Rα) while TGF-β1 induction in the setting of melanoma metastasis is mediated via an IL-13Rα2-dependent mechanism. This evidence concerns the gene IL13 and melanoma.