HSPA8 and cancer: However, inhibition of miR-17-5p and -20a-5p did not alter the HSPA8 expression, suggesting that there is no regulatory correlation between HSPA8 and miR-17-5 and -20a-5p. Although we did not identify the miRNA-related regulatory mechanism of the upregulation of HSPA expression, a hypoglycemic condition seemed to render cancer cells resistant to apoptotic stimulation.