CXCR4 and viral infectious disease: They have demonstrated that peripheral blood PMPs and megakaryocyte-derived MPs can transfer the CXCR4 chemokine receptor from the surface of platelets or megakaryocytes to the surface of CXCR4-null cells that render them more susceptible for T tropic virus infection (X4 HIV strains, for which CXCR4 is essential to enter the cell) [94].