AQP4 and temporal lobe epilepsy: In addition, AQP4 has been implicated in K+ homeostasis and regulation of excitability (Amiry-Moghaddam et al. 2003b; Binder et al. 2004; Haj-Yasein et al. 2012), and loss of perivascular AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy (Alvestad et al. 2013).