The homozygous variant rs4879809 (9:34635598T>C, c.*31A>G), located in the 3′-UTR of SIGMAR1, has been detected in a consanguineous family with adult-onset ALS.11 The authors suggested that c.*31A>G could contribute to the pathogenesis of ALS in this family. This evidence concerns the gene SIGMAR1 and amyotrophic lateral sclerosis.