Furthermore, in situations with plasma insulin concentrations comparable to insulin levels achieved during a hyperinsulinaemic–euglycaemic clamp, the spillover from FAs derived from lipoprotein lipase (LPL)-mediated TAG hydrolysis in adipose tissue has been shown to be less suppressed in obese patients with type 2 diabetes than in non-obese healthy controls [14]. The gene discussed is INS; the disease is type 2 diabetes mellitus.