PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Finally we analyzed whether polymorphisms of PNPLA3, the most important known genetic determinant of NAFLD and highly associated with severity of hepatic damage and fibrosis, influence the entity of EAT, but we did not find any significant association between this genetic marker and EAT, carotid atherosclerosis (cIMT or cplaques) despite patients who carried GG genotype had more severe liver disease.