The I148M variant of patatin-like phospholipase domain-containing-3 (PNPLA3) gene which is involved in lipid remodeling, is actually defined as the major common genetic determinant of NAFLD and it is associated with progression to NASH [9], while its role in atherosclerotic damage has so far been reported only in young patients with NAFLD[10]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.