Patients with CG+GG genotypes of PNPLA3 and patients with EK+K genotypes of TM6SF2 had higher prevalence of NASH (70 and 76% vs 30 and 24%) and of Fibrosis ≥2 (53 and 71% vs 47 and 29) in comparison of patients wild type, but data did not reach statistical significance possibly for the low number of cases. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.