Weobserved that hypomethylation of the CpG at position 1 in IL-6 promoter conferred amore pronounced increase in CHD and AMI risk estimates than that at position 2.Previously, methylation levels of these two CpGs in IL-6 have been differentlyassociated with air pollution exposure.25 These data suggest that differential DNA hypomethylation ofthe two distinct CpGs in IL-6 may reflect different cumulative effects fromendogenous and exogenous exposure factors, and then contribute differently to thesusceptibility to human diseases including CHD. This evidence concerns the gene IL6 and coronary artery disorder.