Recently, gene silencing by DNA methylation has been suggested to be associated withmethylation not only in CpG islands, but also in CpG island shores (i.e., on theisland edges).26,27 In the present study on the association betweenIL-6 promoter methylation and CHD risk, we focused on two individual CpGs within aCpG shore located in the IL-6 gene promoter region, which were described to beassociated with lung function and air pollution exposure.25,28. The gene discussed is IL6; the disease is coronary artery disorder.