In a cross-sectional study, we assessed the levels of serum resistin andleptin, C-reactive protein (CRP), lipid profile and cardiac enzyme tests(AST, CPK, LDH, CK-MB) in 40 CAD patients compared to 40 healthy controls.Anthropometric measurements including weight and height for calculating ofbody mass index (BMI), and waist circumference (WC) were performed forevaluation of obesity. The gene discussed is PIK3C2A; the disease is obesity due to melanocortin 4 receptor deficiency.