Importantly, ATRA-treatment re-localizes PTEN in the nucleus of differentiating cells and this impacts on the abundance of the APC-CDH1-target Aurora A. Therefore, as depicted by our model (Figure 5), the PTEN promoter region is repressed in APL by the PML/RARA repressor complex, while residual amount of PTEN is exported from the nucleus to the cytoplasm, and degraded. The gene discussed is PML; the disease is acute promyelocytic leukemia.