PML and acute promyelocytic leukemia: The chimeric protein has pleiotropic effects and induces APL disease onset and progression [1, 2], by impairing the formation of functional PML nuclear bodies (PML NBs) [3], downregulating tumor suppressor genes [4, 5] through the recruitment of chromatin remodeling enzymes (e.g. co-repressor proteins and histone deacetylases) on their promoters [6], and deregulating transcriptional factors that are critical for myeloid differentiation [6–8].