Inhibition of TNFR2 using anti-sense oligonucleotide technology was observed to reduce experimental liver metastasis by H-59 cells in mice [52], and in one report, growth of syngeneic tumors in TNFR2-deficient mice was reduced compared to wild-type animals [52], while in another study, tumor growth in TNFR2-deficient animals was initially increased but at later time-points was reduced compared to wild-type animals [49]. The gene discussed is TNFRSF1B; the disease is neoplasm.